Santioni's Italian Restaurant"Special" is what we do!

"Wine-Down" Wednesdays!

Every Wednesday is Wine-Down Wednesday!Enjoy $10.00 off pre-selected bottles of wine with the purchase of 2 adult entrees.*Ask your server for details*Wine selections may vary and are subject to change without notice

Follow us:

Family Meal Deal

Running late? Too tired to cook? Pick up a delicious dinner that feeds up to 4 people and have Santioni's at home. Call now to place your take out order. 904-264-1331Choose from the following entrees:
Spaghetti and meatballs (8)- with marinara or meat sauceFettucini AlfredoPenne Rosata with veggiesStuffed Shells (12)- with marinara or meat sauce Eggplant ParmigianaBaked Ziti Parmigiana*Our world-famous garlic bread comes with the meal.
*Add a Family-size House Salad with your choice of dressing for only $9.95 more.

Follow us:



About Us

The first Santioni's Italian Restaurant was established in 1987 by Bruno and Silvana Santioni. In 2003, the Santioni Family brought their love of Italian food to the Fleming Island/Orange Park area. Today, under the new ownership of Michael Mastrocinque, the legacy and legendary fresh, savory recipes continue to be the center of your dining experience.

Whether you are craving a classic Italian dish such mouthwatering Chicken Parmigiana or the eclectic flavor of grouper Sorrento - our extensive menu offers something for everyone. We look forward to providing you with our most gracious service. Buon Appetito!


The best praise for us is our guests’ words. Just look what they say about us!

Just try it. If you’re not absolutely satisfied, tell Bruno and he will make it happen. They’re Italian, so of course they’ll make you feel like family!

Melissa Johnson

Michael Murphy

Ray Guillebeau


  • Address:

    3535 US Highway 17, Ste 15 Fleming Island, FL 32003

  • Phone:

    +1 904-264-1331

  • Hour of Operations:Tuesday -Sunday4pm to 10pm